منابع مشابه
TNAP , a Novel Repressor of NF - B - inducing Kinase , Suppresses NF - B Activation
NFB-inducing kinase (NIK) has been implicated as an essential component of NFB activation. However, the regulatory mechanism of NIK signaling remains elusive. We have identified a novel NIK interacting protein, TNAP (for TRAFs and NIK-associated protein). In mammalian cells, TNAP physically interacts with NIK, TRAF2, and TRAF3 but not IKK1 or IKK2. TNAP specifically inhibits NFB activation indu...
متن کاملSignaling Role of Intracellular Iron in NF- B Activation*
From the Department of Pathology and Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, the Department of Internal Medicine and Center for Gene Therapy, University of Iowa College of Medicine, Iowa City, Iowa 52242, the Division of Biochemistry and Molecular Biology, University of Southampton, Southampton S016 ...
متن کاملNovel calcium-dependent mechanisms of NF-B activation
T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular calcium (Ca 2+ ) to activate the key transcription factors NFAT and NF-κB. The mechanism of NFAT activation by Ca 2+ has been determined; however, the role of Ca 2+ in controlling NF-κB signaling is poorly understood and the source of Ca 2+ required for NF-κB activation is unknown...
متن کاملDifferent modes of NF- B/Rel activation in pancreatic lobules
Algül, Hana, Yusuke Tando, Michael Beil, Christoph K. Weber, Claus Von Weyhern, Günter Schneider, Guido Adler, and Roland M. Schmid. Different modes of NFB/Rel activation in pancreatic lobules. Am J Physiol Gastrointest Liver Physiol 283: G270–G281, 2002; 10.1152/ajpgi.00407.2001.—The eukaryotic transcription factor nuclear factorB (NFB)/Rel is activated by a large variety of stimuli. It has be...
متن کاملInterleukin-1 Induction of NF B Is Partially Regulated by H2O2-mediated Activation of NF B-inducing Kinase*
Reactive oxygen species (ROS) have been demonstrated to act as second messengers in a number of signal transduction pathways, including NF B. However, the mechanism(s) by which ROS regulate NF B remain unclear and controversial. In the present report, we describe a mechanism whereby interleukin-1 (IL-1 ) stimulation of NF B is partially regulated by H2O2-mediated activation of NIK and subsequen...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2010
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a000109